Pharmacological Action of Vishaghna Dravyas from Charakokta Mahakashaya in Drug Induced Hepatotoxicity w.s.r. to Garavishjanya Shotha – A Review

Archana Ankushrao Tidke, Uday Venkatrao Pawade, Ashwin Vitthalrao Nikam

Abstract


Most of the metabolic processes including detoxification of various drugs and xenobiotics occur in the liver. During the detoxification process the reactive chemical intermediates damage the liver. Drug induced hepatotoxicity causes liver damage due to oxidative stress. Hepatotoxicity is an injury to the liver that is associated with impaired liver functions and is a major concern at present. In this modern era, herbal antioxidants have attracted the researches due to its potential and efficacy against drug induced liver injury. Ayurveda describe Vishaghna dravyas as they possess the property to pacify the visha (Toxin) and prevent the reoccurrence of toxic manifestations. Hepatoprotective and Antioxidant activity of Vishaghna Dravyas in Charakokta Mahakashaya has been reported. Most of the Vishaghna dravyas shows pharmacological actions like Shothaghna, Raktashodhaka, Tridoshashamaka, Pittashamaka etc. Drug induced hepatotoxicity can be correlated with the concept of Garavisha in ayurveda. Shotha is one of the manifestations found in Garavisha as well as DIH. Hence Vishaghna dravyas in Charakokta Mahakashaya can be useful in Garavishajanya Shotha and DIH. This review article is an attempt to discuss role of Vishaghna dravyas from Charakokta Mahakashaya as Antioxidant and Garavishaghna in oxidative stress induced hepatotoxicity with special reference to Garavishjanya Shotha.

KEY WORDS: Garavishajanya Shotha, DIH, Oxidative Stress, Antioxidants, Vishaghna Dravyas, Charakokta Mahakashaya.

 


Keywords


Ayurveda

References


Sha Li, Hor-Yue Tan, Ning Wang, Zhang-Jin Zhang, Lixing Loo, Chi-Woon Wong, et al. The role of Oxidative stress and Antioxidant in Liver Diseases. International Journal of Molecular Science 2015; 16: 26087-26124

Vd.Athawale (editor). Ashtang Sangraha of Vagbhata, Uttartantra, Chapter no 40, Verse no 15, Varanasi; Shreemad Aatreya Prakashana; 1980: 843

Dr.Shekhar Namburi, Text book of Agadtantra,Chaukhambha Sanskrita Sansthan, Varanasi; Reprint 2013:178

Vd.Athawale (editor). Ashtang Sangraha of Vagbhata, Uttartantra, Chapter no 40, Verse no. 113-117, Varanasi; Shreemad Aatreya Prakashana; 1980: 843

Yadavji Trikamji (editor). Commentary: Ayurveda Deepika of Chakrapani on Charak Samhita of Charaka, Chikitsasthana, Chapter 12, Verse No,5 Varanasi; Chaukhambha Surbharati Prakashana; Reprint 1992:483

Upadhyay Yadunandan (editor). Commentary: Madhukosha of Shri Vijayrakshita and Shrikanthdatta on Madhavnidanam of Shri Madhavakar, Uttarardha, chapter 36, Verse no.4. 18th edition; Varanasi; Chaukhambha Sanskrit Sansthan; 1989:48

Upadhyay Yadunandan (editor). Commentary: Madhukosha of Shri Vijayrakshita and Shrikanthdatta on Madhavnidanam of Shri Madhavakar, Uttarardha, chapter 36, Verse no.2. 18th edition; Varanasi; Chaukhambha Sanskrit Sansthan; 1989:46

Upadhyay Yadunandan (editor). Commentary: Madhukosha of Shri Vijayrakshita and Shrikanthdatta on Madhavnidanam of Shri Madhavakar, Uttarardha, chapter 36, Verse no.1. 18th edition; Varanasi; Chaukhambha Sanskrit Sansthan; 1989:46

G.Marrone, F.G.Vaccaro, M.Biolato, L.Miele, A.Liguori, C.Araneo, et al. Drug induced liver injury 2017:The diagnosis is not easy but always to keep in mind. European Review for Medical and Pharmacological Science 2017; 21:122-134.

Victor J Navarro, John R Senior. Drug Related Hepatotoxicity. The New England Journal of Medicine 2006; 354:731-739

Priyankar Dey, Manas Ranjan Saha, Arnab Sen. Hepatotoxicity and the present Herbal Hepatoprotective Scenario. Internal Journal of Green Pharmacy 2013;7: 265-73.

G.Marrone, F.G.Vaccaro, M.Biolato, L.Miele, A.Liguori, C.Araneo, et al. Drug induced liver injury 2017:The diagnosis is not easy but always to keep in mind. European Review for Medical and Pharmacological Science 2017; 21:122-134.

Mohan Harsh, Text book of Pathology, 5th edition, JAYPEE brothers Medical Publishers (p) LTD; Reprint 2006; 638.

Jan Schjott (2011). Adverse Effect of Drugs and Toxins on the Liver. Liver Biopsy in Modern Medicine,Dr Yoshika Mizuguchi (Ed),ISBN: 978-983-307-883-0,in Tech, Available From:

http//WWW.intechopen.com/books/Liver-Biopsy-in-Modern/Adverse-Effects-of-Drugs-and-Toxins-on-the-Liver

Mohan Harsh, Text book of Pathology, 5th edition, JAYPEE brothers Medical Publishers (p) LTD; Reprint 2006; 638.

Sael Casas-Grajale, Pablo Murial. Antioxidant in Liver Health. World Journal of Gastrointestinal Pharmacology and Therapeutics 2015; 6:59-72.

Priyankar Dey, Manas Ranjan Saha, Arnab Sen. Hepatotoxicity and the present Herbal Hepatoprotective Scenario.Internal Journal of Green Pharmacy 2013;7: 265-73.

Jan Schjott. (2011).Adverse Effect of Drugs and Toxins on the Liver.Liver Biopsy in Modern Medicine,Dr Yoshika Mizuguchi (Ed),ISBN: 978-983-307-883-0,in Tech, Available From:

http//WWW.intechopen.com/books/Liver-Biopsy-in-Modern/Adverse-Effects-of-Drugs-and-Toxins-on-the-Liver

Halina Cichoz-Lach, Agata Michalak. Oxidative Stress as a Crucial Factor in Liver Disease. World Journal of Gastroenterology 2014; 20:8082-8091

Sael Casas-Grajale, Pablo Murial. Antioxidant in Liver Health. World Journal of Gastrointestinal Pharmacology and Therapeutics 2015; 6:59-72.

Bijita Chutia, Khagen. Free radical mediated disease and their prevention: An Ayurvedic Perpective. International journal of ayurveda and Pharma Research 2016;4: 84-91.

Yadavji Trikamji (editor). Commentary: Ayurveda Deepika of Chakrapani on Charak Samhita of Charaka,Sutrasthana,Chapter 4, Verse no 8, Varanasi; Chaukhambha Surbharati Prakashana; Reprint 1992:31

Yadavji Trikamji (editor). Commentary: Ayurveda Deepika of Chakrapani on Charak Samhita of Charaka,Sutrasthana,Chapter 1, Verse no 97, Varanasi; Chaukhambha Surbharati Prakashana; Reprint 1992: 22

Yadavji Trikamji (editor). Commentary: Ayurveda Deepika of Chakrapani on Charak Samhita of Charaka,Sutrasthana,Chapter 4, Verse no 8-18, Varanasi; Chaukhambha Surbharati Prakashana; Reprint 1992:31-34

Dr. Pandey GS (editor). Commentary by Dr. Chunekar KC on Bhavprakash Nighantu of Shri Bhavmishra, 8th edition, Varanasi; Chaukhambha Bharati Academy;1988

Lee Hyeong-seon, Li Li, Hyun-Kyung Kim, Dinesh Bilehal,Wei Li, Dong-Seok Lee, Yong-Hokim.The Protective effect of Curcuma longa Linn extract on Carbon trtrachloride induced hepatotoxicity in rats via Upregatation of Nrf2.Journal of Microbiology and Biotechnology 2010;20:1331-1338

AKT, Gulcin I, Antioxidant and Radical Scavenging properties of Curcumun.Chem Biol Interact 2008;174:27-37

Guntupalli M Mohana Rao, Chandana V Rao, Palpu Pushpangadan, Annie Shriwaikar, Hepatoprotective effect of Rubiadin a major constituent of Rubia Cordifoliya Linn. Journal of Ethnopharmacology 2006; 103: 484-490

Shweta Lodia, Leena Kansala. Antioxidant activity of Rubia Cordifolia against Lead Toxicity. International Journal of Pharmaceutical Science and Research 2012;3:2224-2232

S U Yanpallewar, S Sen, S Tapas, Mohan Kumar, S S Raju, SB Acharya. Effect of Azadirecta Indica on Paracetamol induced hepatic damage in albino rats. Phytomedicine 2003; 10: 391-396

Gayatri Nahake, R k Sahu.Antioxidant activity in bark and roots of Neem (Azadirachta indica) and Mananeem(Melia Azedarach). Continental Journal of Pharmaceutical Science 2010; 4: 28-34

Varsha Sharma, R C Agrawal.In vivo Antioxidant and Hepatoprotective Potential of Glycyrrhiza Glabra extract on Carbon tetrachloride (CCl4) induced oxidative stress mediated hepatotoxicity.International Journal of Research in Medical Science 2014; 2:314-320

Kuppan Nithiananthan, Murugesan Shyamala, Yeng Chen, Lachimanan Yoga Latha, Subramanion L.Jothy, Sreenivasan Sasidharan. Hepatoprotective Potential of Clitoria Ternatea leaf extract against Paracetamol induced Damage in Mice. Molecules 2011; 16:10134-10145

Vidhya Ramaswamy, Neethu Vargheses, Ancy Simon. An investigation on Cytotoxic and Antioxidant properties of Clitoria Ternatea L.International Journal of drug discovery 2011;3:74-77

Venu Gopala Rao Konda, Madhavi Eerike, Lakshmipathy Prabhu Raghuraman, Maignana. Antioxidant and Nephroprotective activities of Aconitum Heterophyllum Root in Glycerol induced acute renal failure in rats.Journal of Clinical and Diagnosic Research 2016; 10: 1-5

Debashish Paramanick, Ravindra Pandey, Shive Shankar Shukla, Vikas Sharma. Primary Pharmacological and other important findings on the medicinal plant Aconitum heterophyllum (Aruna). Journal of Pharmacopuncture 2017;20:89-9

Tritha Ghosh, Tapan Kumar Maity,Mrinmay Das,Anindya Bose, Deepak Kumar Dash.In Vitro Antioxidant and Hepatoprotective activity of ethenolic extract of Bacopa Monnieri Linn aerial parts.International Journal of Pharmacology and Therapeutics 2007;6:77-85

Netranjali Dhamal, Mihir Patel, Shrikant Pawar. Evaluation of Jaminum grandiflorum for hepatoprotective activity in Isoniazid induced liver damage.International Journal of Pharmaceutical Science and research 2012;3:2568-2573

Umamaheswari M, Asokkumar K, Rathidevi R, Sivashanmugan AT, Subhadradevi V, Ravi TK. Antiulcer and in vitro Antioxidant activity of Jasminum grandiflorum L. Journal of Ethnopharmacology 2007;110:464-70

A Kapil, IB Koul, OP Suri. Antihepatotoxic effect of Chlorogenic acid from Anthocephalus Cadamba. Phytotherapy Research 1995;9:189-193

Vishnu Kumar, Farazana Mahdi, Ramesh Chander, Raniana Singh, Abbas Ali Mahal. Hypolipidemic and Antioxidant activity of Anthocephalus Indicus (Kadamba) root extracts.Indian Journal of Biochemistry and Biophysics 2010;47: 104-109

GM Mohana Rao, Ch Venkateswararao, AKS Rawat, P Pushpangadhan, A Shirwaikar. Antioxidant and Hepatoprotective activity of Hemidesmu Indicu R.Br. Acta Pharmaceutical Turcica 2005; 47: 107-113

Usha Venkatachalam, Suriyaathana Muthukrishnan.Hepatoprotective activity of Desmodium Gangeticum in Paracetamol induced liver damage in rats. Biomedicine and Preventive Nutrition 2013; 3: 273 - 277

R Govindarasan, M Vijaykumar, Ch U Rao, A Shirwaikar, Santhosh Kumar, AKS Rawat P. Anti-inflammatory and Antioxidant activities of Demodium Gangeticum fraction in carrageenan induced inflamed rats.Phytotherapy Research 2007; 21: 975-979

Shirodw DS, Jain BB, Mahendra Kumar CB, Setty SR. Hepatoprotective and Antioxidant Effects of Albizia Lebbeck against Thioacetamide induced Hepatotoxicity. Journal of Chemical and Pharmaceutical Science 2012; 5: 199-204

Yadavji Trikamji (editor). Commentary: Ayurveda Deepika of Chakrapani on Charak Samhita of Charaka,Sutrasthana,Chapter 4, Verse no 11, Varanasi; Chaukhambha Surbharati Prakashana; Reprint 1992:33

Dr.G S Pandey (editor). Commentary by Dr. Chunekar KC on Bhavprakash Nighantu of Shri Bhavmishra, Haritakyadi Varga, Verse no.196-197,8 edition,Varanasi; Chaukhambha Bharati Academy;1988: 114

Dr.G S Pandey (editor). Commentary by Dr. Chunekar KC on Bhavprakash Nighantu of Shri Bhavmishra, Haritakyadi Varga, Verse no. 188-191,8 edition,Varanasi; Chaukhambha Bharati Academy;1988: 191

Dr.G S Pandey (editor). Commentary by Dr. Chunekar KC on Bhavprakash Nighantu of Shri Bhavmishra, Guduchyadi Varga, Verse no. 93-96,8 edition,Varanasi; Chaukhambha Bharati Academy;1988: 328

Prof. Priyavrata Sharma, Dr. Guru Prasad Sharma (editor). Kaiyadeva Nighantu, Aushadhivarga, Verse no 880,Reprint edition, Varanasi; Chaukhambha Orientalia; 2013:163.

Dr. Zarkhande Oza, Vd. Umapati Mishra(editor). Dhanwantari Nighantu, Guduchyadi Varga, Verse no 30, edition 2004, Varanasi; Choukhamba Surabharati Publication ;2004: 23.

Dr.G S Pandey (editor). Commentary by Dr. Chunekar KC on Bhavprakash Nighantu of Shri Bhavmishra, Haritakyadi Varga, Verse no. 145-146, 8 edition,Varanasi; Chaukhambha Bharati Academy;1988: 65

Dr.G S Pandey (editor). Commentary by Dr. Chunekar KC on Bhavprakash Nighantu of Shri Bhavmishra, Guduchyadi Varga, Verse no. 112, 8 edition,Varanasi; Chaukhambha Bharati Academy;1988: 242

Dr.G S Pandey (editor). Commentary by Dr. Chunekar KC on Bhavprakash Nighantu of Shri Bhavmishra, Haritakyadi Varga, Verse no. 213-214, 8 edition,Varanasi; Chaukhambha Bharati Academy;1988: 126

Dr.G S Pandey (editor). Commentary by Dr. Chunekar KC on Bhavprakash Nighantu of Shri Bhavmishra, Guduchyadi Varga, Verse no. 283, 8 edition,Varanasi; Chaukhambha Bharati Academy;1988: 461

Dr.G S Pandey (editor). Commentary by Dr. Chunekar KC on Bhavprakash Nighantu of Shri Bhavmishra, Pushpa Varga, Verse no. 27-28, 8 edition,Varanasi; Chaukhambha Bharati Academy;1988: 491

Prof. Priyavrata Sharma,Dr.Guru Prasad Sharma (editor).Kaiyadeva Nighantu, Aushadhivarga,Verse no 1474,Reprint edition, Varanasi; Chaukhambha Orientalia; 2013:273.

Prof. Priya Vrat Sharma (editor).Priya Nighantu, Sharadi Varga, Verse No 75, Varanasi; Chaukhambha Surabharati Prakashana; edition 2004: 134

Dr.G S Pandey (editor). Commentary by Dr. Chunekar KC on Bhavprakash Nighantu of Shri Bhavmishra, Guduchyadi Varga, Verse no. 238, 8 edition,Varanasi; Chaukhambha Bharati Academy;1988: 426

Dr.G S Pandey (editor). Commentary by Dr. Chunekar KC on Bhavprakash Nighantu of Shri Bhavmishra, Guduchyadi Varga, Verse no. 31-32, 8 edition,Varanasi; Chaukhambha Bharati Academy;1988: 285

Dr. Zarkhande Oza, Vd. Umapati Mishra(editor).Dhanwantari Nighantu, Guduchyadi Prathama Varga, Verse no 86,edition 2004, Varanasi; Choukhamba Surabharati Publication ;2004: 38

Dr.G S Pandey (editor). Commentary by Dr. Chunekar KC on Bhavprakash Nighantu of Shri Bhavmishra, Guduchyadi Varga, Verse no. 13-14, 8 edition,Varanasi; Chaukhambha Bharati Academy;1988: 518

Lakshman K, Shivaprasad H N, Jaiprakash B, Mohan S.Anti-Inflammatory and Antipyretic activities of Hemidesmus Indicus Root Extract. Afr. Journal of Traditional, Complementary and Alternative Medicines 2006; 3: 90-94

.


Full Text: PDF

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.