“A Review of Pharmacological Action of Vishaghna dravyas from Charakokt Mahakashay in Drug Induced Nephrotoxicity w.s.r. to Garavishajanya Shotha”

Manasi Subhash Brid, Ashwin Vithalrao Nikam, Uday Venkatrao Pawade

Abstract


Kidney being a major organ of excretion, is susceptible to the damage caused due to variety of toxins such as xenobiotics, drugs, environmental toxins etc. Nephrotoxicity is impairment of renal function which occurs due to adverse effects of these toxins on kidney. Oxidative stress is implicated as one of the mechanisms of drug induced nephrotoxicity. Drug induced nephrotoxicity (DIN) can be correlated with the concept of gara visha in Ayurveda. Shotha is one of the important manifestations found in gara visha as well as drug induced nephrotoxicity. Vishaghna dravyas from Charakokt mahakashays possess shothaghna, raktashodhak, tridoshashamak and mutral properties. Also, these dravyas have been reported for antioxidant and nephroprotective potential. Hence, these vishaghna dravyas from Charakokt mahakashays can be useful in Garavishajanya Shotha as well as drug induced nephrotoxicity. This review article is an attempt to discuss the role of vishaghna dravyas as antioxidant and gara vishaghna in oxidative stress induced nephrotoxicity with special reference to Garavishajanya Shotha.

KEY WORDS: DIN, Oxidative Stress, Antioxidants, Garavishajanya Shotha, Vishaghna Dravyas, Charakokt Mahakashay.


Keywords


Ayurveda

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