CLASSICAL ASHTAVAIDYAN AYURVEDIC THERAPY IN THE FUNCTIONAL IMPROVEMENT OF PATIENTS WITH ANKYLOSING SPONDYLITIS: AN OPEN LABEL, SINGLE ARM CLINICAL STUDY
Background: Arthritis and various musculo-skeletal disorders are the leading causes of disability in persons between 18 to 65 years of age and are common causes of disability related to employment. Among them ankylosing spondylitis is a chronic, systemic, inflammatory disease that affects primarily the sacroiliac joints and spine with the symptoms of muscular spasm, stiffness and limitation of movement of spine. It is classified under seronegative spondyloarthritic disease.Traditional practice of Ashtavaidyan Ayurveda line of management has been tried to evaluate the efficacy in ankylosing spondylitis.A combined treatment with internal medication and external therapeutic procedures of Ayurveda has been taken up to assess the evaluate the effect on the functional improvement and safety in ankylosing spondylitis.
Diagnosed cases of ankylosing spondylitis(n=30) (20-60 yrs) have undergone the prescribed classical Ashtavaidyan Ayurvedic therapy;the total study period was 57 days which included 21 days each at inpatient and outpatient basis and 15 days of follow up. Initially Pizhichil (Kayaseka)with Ketakeemooladi Taila with Panchatiktaka Ghrita was performed along with internal medications for first 7 days later same internal medication is continued with Sathaila Tila Pinda Sweda and followed by PanchatikthakaKsheera Basti for last 7 days. Same internal medicines and oil application were continued for next 21 days on outpatient basis and Balaguluchyadi Taila was applied regularly on scalp for all these days.
Result: The response of treatment was assessed periodically with respective parameters and was showed significant improvement. The functional improvement was evaluated by using the BASDAI score, DAS-28 score, disability index, SF-36 (quality of life index) and global assessment of disease activity scale and it was that there were significant changes in all the above scales. The laboratory parameters used to evaluate the liver and kidney functions did not show any significant change that indicates the prescribed treatment is safe.
Conclusion: Traditional Ashtavaidyan Ayurveda therapy is s effective in improving functional ability in Vatarakta vis-à-vis ankylosingpondylitis over a period of 42 days. Moreover, there was no adverse drug reaction recorded during as well there was no significant change observed in liver and renal function tests.
Keywords: Ayurveda, ankylosing spondylitis, Vatarakta, Pizhichil, Gandarvasthadi Kashaya, Kethakeemooladi Taila, Ksheera basthi, HLA-B27
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