Antiulcer activity of Rasa Parpati against Pylorus ligation induced Gastric ulcer in Rats
Background: Rasa Parpati is one of the Rasayoga having less toxicity, cost effective and high therapeutic value specially in GI disorders including ulcers.
Aim: The aim of this study is to evaluate the Antiulcer activity of Rasa Parpati by pyloric ligation method in Albino rats and to know its effect on gastric secretions.
Subjects and Methods: The Anti ulcer activity of Rasa Parpati was investigated at different doses using Ranatidine as standard drug. The effect was studied by calculating the total number of ulcers, Ulcer index, its Percentage of inhibition and histological study and the effect on gastric secretions was studied by its Volume, pH, Total Acidity and Free acidity.
Results: Rasa parpati have shown significant decrease in the number of ulcers and ulcer index and significant increase in % inhibition of ulcers as compared with control group. Histological studies revealed that ulcer control group exhibited severe damage of gastric mucosa, along with edema and leucocytes infiltration of submucosal layer compared to rats pre-treated with Rasa parpati which showed gastric mucosal protection, reduction or absence of edema and leucocytes infiltration of submucosal layer. There was significant reduce in the Volume, free acidity and Total acidity and increase in its pH.
Conclusion: Results indicate that Rasa parpati possess significant Anti ulcer property which could be either due to cytoprotective action of the drug or by reducing the gastric secretion or by strengthening of gastric mucosa and thus enhancing mucosal defense
Key words: Rasa parpati, Gastric ulcer, Gastric juice, cytoprotection, Anti ulcer activity
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