Harshitha KJ, Kavita MB, Baskaran V, Gurubasavaraj Y



Background: Diabetes Mellitus [DM] is one among the group of metabolic diseases, in which there is high blood sugar levels over a prolonged period. Presently, more than 7.1% of India’s adult population affected by this disease.1 yava mantha administered as a therapeutic diet is expected to decrease the glucose levels in DM.  In the present study, the adopted samskara (processing) is manthana (churning). As per the verse “samskaro hi gunantaradhanam ucchayte  (processing brings in the quality change/improvement)”2 , by means of churning, it is expected to improve the quality of yava (Barley). Because DM is a yapya vyadhi (disease not curable but can be managed), importance has been focused on the use of traditional food preparations to tackle this disease.

Objectives: The main objective of this study was to study the inhibitory effect of yava mantha on alpha amylase and alpha glucosidase, two intestinal enzymes, and glucose lowering potential of yava mantha.

Materials and methods: Work was conducted at CFTRI, Mysore. Barley was purchased from departmental store, cleaned, dry roasted, milled and stored in an air tight container.

yava mantha was prepared by adding 48 grams (one  Pala) of powdered yava (yava saktu), 12 grams (one Karsha ) of ghee (Go Ghrita) and 192 ml of water ( 4 Pala) was added and churned using magnetic churners at the rate of 520 rpm till the homogenous mixture is obtained. i.e., 1:1:4 parts.

Results: On comparison with different samples, sample churned for 20 minutes has higher inhibition activity. The inhibition concentration (IC-50, mg/ml) of yava mantha churned for 20 minutes (B1) on alpha glucosidase enzyme (methanol extract) was 1.40mg/ml , on alpha glucosidase enzyme (methanol extract) was 6.34 mg/ml, on alpha glucosidase enzyme (water extract) was 189.17 mg/ml.

Discussion and conclusion: The inhibitory effect of yava mantha on alpha-amylase and alpha-glucosidase activities in vitro indicate that, there is hypoglycemic potential for yava mantha and can be considered as a very good anti-diabetic plant source.




Diabetes can be controlled in 80% of cases in india”/ ANS.news.biharprabha.com. Retrieved 6 feb 2014.[cited on 12 feb 2016]

Kavita MB, Sandeep S, Baskaran V, Harshitha KJ, 2017, Samskara (Processing) Changes the Quality of Food: An Analytical Study. Int J Complement Alt Med, 7(4): 00232. DOI: 10.15406/ijcam.2017.07.00232)

Indian heart association Why south asians facts Web.30 apr 2015.[cited on 12 feb 2016] URL< http:// indian heart association org/why-indians-why- south asian /overview/>

Sharma priyavat, sharma guruprasad. Kayyadeva nigantu pathya apathya vibhodaka. Varanasi: chaukambha orientalia ; 2009 kritannavarga;188-190,p.430-431

Agnivesha, charaka, dridabala. Charakasamhita, trikamji vaidya yadavji. Varanasi:chaukambha series publications;2011; chikitsasthana 6/32-33,p.447 )

Sharangadhara; sharangadhara samhitha,srivastava shailaja.varanasi. Chawkambha orientalia; 3rd ed 2003. madyama khanda phanta kalpana[8-12].p.164-165

Sharangadhara; sharangadhara samhitha, srikantha murthy.varanasi. Chawkambha orientalia; 2012. madyama khanda kwatha kalpana[6].p.57

Minaiyan et al (2014 ,Effect of Hordeum vulgare L. (Barley) on blood glucose levels of normal and STZ-induced diabetic rats, .( Res Pharm Sci. 2014 May-Jun; 9(3): 173–178.

Clinical assessment of dietary interventions and lifestyle modifications in Madhumeha (type- 2 Diabetes Mellitus) Ayu. An international quarterly journal of research in ayurveda, 2014 Oct-Dec; 35(4): 391–397.doi: 10.4103/0974-8520.158997

J Abe, U Sidenius,B Svensson, Arginine is essential for α-amylase inhibitory activity of the α-amylase/subtilisin inhibitor (BASI) from barley seeds, Biochemical Journal Jul 01, 1993,293(1)1 51-155

Kumara Rajesh et al , physicochemical and nutritional evaluation of Yava(Hordeum vulgare) Int.Res.J.Pharm.2015:6(1):70-72)

Gupta sanjat et al, utility of samskara in pharmaceutics w.s.r to sandhana kalpana,Indian journal of ancient medicine and yoga.2(4), oct-dec, 2009.

Charaka samhita, agnivesha, chakrapanidutta virachita,Varanasi.chawkambha orientalia sutrasthana 13/13. Pg.no 82. 2015

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