Evaluation of the effect of an Ayurvedic Dietary Formulation (Panchakolasiddha yavagu) in reducing the Disease Activity Score (DAS28 using C‐reactive protein) among Amavata patients

  • Muhammed Safeer P I Assistant Professor Vaidyaratnam P S Varier Ayurveda College
  • Surendran E Emeritus Professor Department of Kayachikitsa VPSV Ayurveda College, Kottakkal
  • Prakash Mangalasseri Associate Professor VPSV Ayurveda College, Kottakkal
Keywords: Panchakolasiddha yavagu, Disease Activity Score, Amavata


Background and objectives: Amavata, is one among the multiple joint disorders explained in Ayurvedic classics. Its pathology is explained to be beginning with the sluggish functioning of the bio fire (agni) or the digestive capacity. The disease is having high prevalence rate and is of crippling nature. Practically there is no effective proven intervention in popular practice to break the chains in the pathogenesis by correcting the bio-fire. Hence it was a high time to develop such an intervention with a therapeutic diet restricting all other medicine and food to check the pathogenesis and thereby the disease activity.

Aim: The study attempted to evaluate effect of an Ayurvedic dietary formulation, Panchakolasiddha yavagu in reducing the disease activity by using the Disease Activity Score (DAS 28) using CRP, among amavata patients.

Settings and Design: Vaidyaratnam P S Varier Ayurveda College, Kottakkal, Open clinical trial

Methods: 20 participants were selected. Intervention was till the attainment of proper digestive capacity, the optimum functioning of bio fire or maximum up to 10 days. Panchakolasiddha yavagu prepared as per the classical reference was given in morning and evening restricting all other food and medicine. Pain was assessed daily using Numerical Rating Scale. Disease activity score was used to assess the symptomatic relief.

Statistical analysis used: Paired t test was used to assess effect of intervention. Statistical analysis was done by using Microsoft Office 2007 Excel, Graphpad InStat version 3, and IBM SPSS Statistics version 16.

Results: There was highly significant reduction in pain (p<0.001), significant reduction in disease activity (p<0.001). The intervention shows significant results in reducing the CRP levels (p<0.05).

Conclusion:  Administration of the Ayurvedic dietary preparation, panchakolasiddha yavagu was highly effective in reducing the disease activity score DAS28. It was highly effective in reducing the pain and maximum significant change is observed between day 7 and day 8. It also helped to reduce the CRP levels significantly. 

Author Biography

Muhammed Safeer P I, Assistant Professor Vaidyaratnam P S Varier Ayurveda College

Assistant Professor

Department of PG Studies in Swasthavritta