Akarkara: a versatile medicinal plant – a review

VIKAS KUMAR, Anand Kumar Chaudhary

Abstract


Ayurveda, the science of living beings is the ancient system of medicine of India. Since Indian philosophy is reflected in Ayurveda, the principles of Ayurveda are very pervasive. The actual purpose of Ayurveda is to live the life with physical, mental, social and spiritual wellbeing. In Ayurveda numerous plants are described for fulfilling its purpose. One of those plants is Akarkara (Anacyclus pyrethrum L.). Basically, Akarkara is described in Unani system of medicine as an amazing drug used in various ailments. Later on, due to its multidimensional uses, it also has been included in the Ayurvedic text written in & after the medieval era. Shodhal Nighantu has described firstly Akarkara as one of the potent aphrodisiac drug. Here, an attempt is made to review its scattered multi-dimensional health benefits quoted in Ayurvedic and Unani treatises and validated through scientific researches in laboratories.


Keywords


Akarkara, Anacyclus pyrethrum, Aphrodisiac Drug

References


Shastri R D et al. editors, (1st ed.).Vidyotini Hindi Commentary, Charaka Samhita, Sutrasthan; Chapter 30, Verse 26.Varanasi; Chaukhambha Bharati Academy, Reprinted 2005.

Shastri Ambikadutta, Commentator Ayurveda-Tattva-Sandeepika Hindi Commentary, Sushruta Samhita Sutrasthan; Chapter 01, Verses-22. Varanasi; Chaukhambha Sanskrit Sansthan, Reprinted 2010.

Sharma P V, Ayurvada Ka Vaigyanika Itihasa Page No.-349. Varanasi; Chaukhambha Orientalia. Reprinted 2008.

Tripathi I D, (4th ed), Commentator Vidyotini Hindi Commentary, Gada Nigraha Vol. I Prayoga Khand-Churnaadhikar, Varanasi; Chaukhambha Sanskrit Sansthan 2003.

Srivastava Shailaja, Commentator Jeewanprada Hindi Commentary, Sharangadhara Samhita; Madhyam Khanda Chapter 6, Verse 163-165. Varanasi; Chaukhambha Orientalia, Reprint 2013.

Shodhal Nighantu, Chapter 1, Verse 688.

Dwivedi Vishwanath, (9th ed) Hindi Commentator, Bhavaprakash Nighantu, Guduchyadi varga; 3/64. Page No.-164-165, Varanasi; Motilal Banarasidas, Reprint 1998.

Shastri L P, Commentator Vidyotini Hindi Commentary, Yogratnakar (Uttarardha) page no. - 429-430, Varanasi; Chaukhambha Prakashan, Reprint 2012.

Mishra S N, Commentator Siddhiprada Hindi commemtary, Bhaishajya Ratnavali, Chapter 74, Verse 372, Chapter 75, Verse 22. Varanasi; Chaukhambha Surbharati Prakashan, 2005 Edition.

Sharma P V, Dravyaguna Vigyana Vol. II, Chapter VII, Page No.-578-579. Varanasi; Chaukhambha Bharati Academy.

Vaidya Thakkur G K, Vaidyaka Chikitsa Saara(Poorvardha). Page No.-85-86, Hindi Translation, New Delhi; Director CCRAS 2008.

Sharma Hariprapanna, Rasa Yoga Sagar: Vol. I, Page No. 262-63, 265, 268, 272-73; Varanasi; Chowkhamba Krishnadas academy, Reprint 2010.

Rasa Tantra Saara Evam Siddha Prayoga Sangraha(14th ed): Vol. II, Page No. 599, 600, 614, 616, 618; Ajmer (Raj.); Krishna Gopal Ayurveda Bhawan (Dh. T.); 1999.

Pathak Ramraksha, Ayurveda Saara Sangraha: Gutika/Vati Prakaran, Naini; Shri Vaidyanath Ayurveda Bhavana Limited, Reprint 2008.

Puri H S, Rasayana- Ayurvedic herbs for longevity and rejuvenation. London : taylor & Francis. 2003.

Ibne Baitar, “Al-Jam-e-ul-Mufradat-Al-Adviah-Wal-Agh-ziya (Urdu translation),” CCRUM publication, New Delhi, 1999.

Ibne Sina. Alqanun Fil Tib. (English translation by Dept of Islamic Studies Jamia Hamdard). Part 2. New Delhi: Hamdard University; 1998: 316, 317.

The Wealth of India Vol. X, Page No.-11-12, New Delhi; National Institute of Science Communication and Information Resource CSIR; 1985: 248, Reprinted 2009.

Kokate C K, Porohit A P, Gokhale S B; Pharmacognosy; Nirali Prakashan, 37 edition; Page No. 578.

Dymock W, Warden C J H, David H; Pharmacographia Indica, a History of the Principal Drugs of Vegetable Origin. Vol. 2. New Delhi: Shrishti Book Distribution; 2005: 277-280.

Anonymous, The Ayurvedic Pharmacopoeia of India, Department of AYUSH, Ministry of Health and Family Welfare, Government of India, New Delhi; Part I Vol. II Page No.-12-14.

Kushwaha Munna N, Vijay Singh Jatav, Swatantra Pandey; Plant Anacyclus pyrethrum -A Review; Research Journal of Pharmacognosy and Phytochemistry. 4(3): May-June 2012, 164-17

Kalam M A, Karim M S, Anzar M A, Sofi G, Ahmad G and Shahzad A et al., Aqer Qerha (Anacyclus pyrethrum DC.) A Nobel Drug of Unani System of Medicine-A Review; IJP, 2015; Vol. 2(3): 116-122.

Anonymous. Standardization of single drugs of Unani medicine. Part 2. New Delhi. CCRUM, Ministry of Health and Family Welfare Govt. of India; 1992: 22-26.

The wealth of India “A dictionary of Indian raw material and Industrial product; 1948; 9; 250-254.

Kabeeruddin H M; Ilmul Advia Nafeesi. Aijaz Publication New Delhi; 2007: 290, 291, 307.

Zakaria R M B; Al-Mansoori. (Urdu translation by CCRUM). New Delhi: Ministry of Health and Family Welfare, Govt. of India; 1991: 144-145.

Shaikh Imtiyaz, Mohd. Tariq, Shahid S. Chaudhary; Aphrodisiacs Used in Unani System of Medicine; Journal of Biological and Scientific Opinion, Vol I (3), 2013.

Mathur M, Herbal Aphrodisiac their Need, Biology and Status: Global and Regional Scenario; Journal of Natural Products, Vol. 5(2012):131-146.

Kritikar K R, Basu B D, (2nd ed), Indian Medicinal Plants Vol. II, Page No.-1365-1368, Dehradun; International Book Distributors, Reprinted 2006.

Reveiws on Indian Medicinal Plants: Vol II, Page No. 247-250. New Delhi; ICMR, Ansari nagar 2004.

Gulland J M and Hopton G U; “Pellitorine, the Pungent Principle of Anacyclus pyrethrum,” Journal of Chemical Society, 1930, pp. 6-11.

Burden R S and Crombie L; “Amides of Vegetable Origin. Part XII. A New Series of Alka-2, 4-Dienoic Tyramine-Amides from Anacyclus pyrethrum D C,” Journal of the Chemical Society C: Organic, No. 19, 1969, pp. 2477-2481.

Sharma Vikas, Thakur Mayank, Chauhan Nagendra Singh and Dixit Vinod Kumar; Effect of Petroleum ether extract of Anacyclus pyrethrum DC. On sexual behaviour in male rats. Journal of Chinese Integrative Medicine, August 2010, Vol. 8, No. 8.

Chauhan Nagendra Singh, Sharma V, Dixit V K, and Thakur Mayank; Effect of Asteracantha longifolia seeds on the sexual behaviour of male rats, Nat Prod Res. 2009; 14: 1-9.

Thakur M, Chauhan N S, Bhargava S, Dixit V K; A comparative study on aphrodisiac activity of some Ayurvedic herbs in male albino rats. Arch Sex Behav. 2009; 38(6): 1009-1015.

Sharma Vikas, Boonen J, Spiegeleer B D and Dixit V K; Androgenic and Spermatogenic Activity of Alkylamide-Rich Ethanol Solution Extract of Anacyclus pyrethrum DC. Phytotherapy Research, Vol. 27, Issue 1, Page No. 99-106, January 2013.

Haghighi P. et al., Anacyclus pyrethrum and Tribulus terrestris simultaneously improve the Sexual Parameters of Wistar Rats: International Journal of Fertility and Sterlity, 2012, Vol 06, 59-60.

Chauhan N S, Sharma V, Dixit V K and Thakur M; A Review on Plants Used for Improvement of Sexual Performance and Virility BioMed Research International Volume 2014, Article ID 868062, 19 pages.

Dilip K. Jani, Comparative Clinical Study on Anacyclus pyrethrum and Spilanthus acmella as Akarakarabha in Erectile Dysfunction and Premature Ejaculation. Shodha Samagya, Vol.-01 No. 04, Oct-Dec. 2007.

Sarieh Shahra, Javad Sharifi Rad, Farzaneh Mohammadzadeh Rostami, Mohammad Reza Shahraki, and Mohammad Reza Arab et al., Effects of Aqueous Root Extracts of Anacyclus pyrethrum on Gonadotropins and Testosterone Serum in Adult Male Rats. American Journal of Phytomedicine and Clinical Therapeutics. Vol. 2, No.6, Page No.-767-772, 2014.

Sharma Vikas, Thakur Mayank, Chauhan Nagendra Singh, Dixit Vinod Kumar; Evaluated the Anabolic, Aphrodisiac and Reproductive Activity of Anacyclus pyrethrum DC in Male Rats Sci Pharm 77:97–110, 2009.

Shamloul R, Natural aphrodisiacs. The J. Indian J. Experimental Biol., 30(5): 418-20, 2010.

Usmani Afreen, Khushtar Mohd, Arif mohd, Siddiqui Mohd Aftab, Singh Satya Prakash, Mujahid Mohd et al., Pharmacognostic and phytopharmacology study of Anacyclus pyrethrum: An insight; Journal of Applied Pharmaceutical Science Vol. 6 (03), pp. 144-150, March, 2016.

Sharma Poonam, Bhardwaj Priyanka, Arif Tasleem, Khan Imran, and Singh Rambir et al., Pharmacology, Phytochemistry and Safety of Aphrodisiac Medicinal Plants: A Review. RRJPTS | Volume 2 | Issue 3 | July - September, 2014.

Gautam O P, Verma Savita, Jain S K; Anticonvulsant and Myorelaxation Activity of Anacyclus Pyrethrum DC (Akarkara) Root Extract; Pharmacologyonline 1: 121-125, 2011.

Zaidi Syed Mohd Abbas, Pathan Shadab Ahmad, Singh Surender, Shakir Jamil, Farhan Jalees Ahmad, Khare Roop Krishen et al., Anticonvulsant, Anxiolytic and Neurotoxicity Profile of Aqarqarha (Anacyclus pyrethrum) DC Root Ethanolic Extract Pharmacology & Pharmacy, 2013, 4, 535-541.

Pahuja M, Mehla J, Reeta K H, Joshi S, Gupta Y K; Root extract of Anacyclus pyrethrum ameliorates seizures, seizure-induced oxidative stress and cognitive impairment in experimental animals. Epilepsy Res 2012; 98:157-165.

Tyagi Satyanand, Mansoori Mohd Hashim, Singh Narendra Kumar, Shivhare Manoj Kumar, Bhardwaj Poonam and Singh Rahul Kumar et al. Antidiabetic Effect of Anacyclus pyrethrum DC in Alloxan Induced Diabetic Rats; European Journal of Biological Sciences 3 (4): 117-120, 2011.

Jalayer Naderi N, Niakan M, Khodadadi E; Determination of Antibacterial Activity of Anacyclus pyrethrum Extract against Some of the Oral Bacteria: An In Vitro Study J Dent Shiraz Univ Med Scien. 2012 June; 13(2): 59-63

Kumar A, Verma U. and Ritesh S; Antimicrobial activity of alcoholic extract of Anacyclus pyrethrum. Ind. J. plant sci., 1: 120-123, 2012

Selles C H, El Amine D M, Allali H and Tabti B; Evaluation of antimicrobial and antioxidant activities of solvent extracts of Anacyclus pyrethrum L., from Algeria. Mediter. J. Chem., 2: 408-415.2012.

Sujith K, C Ronald Darwin, V Suba; Antioxidant Activity of Ethanolic Root Extract of Anacyclus pyrethrum; International Research Journal of Pharmacy 2011, 2(12), 222-226.

Priya P, Anandraj Arul C A, Kirtania Parbati; Study of Anti-pyretic Activity of Ethanolic Extract in Anacyclus pyrethrum DC; International Journal of Institutional Pharmacy and Life Sciences 4(2): March-April 2014.

Reddy Divya, Study of the Diuretic Activity in Aqueous Extract of Root of Anacyclus pyrethrum in Albino Wistar rats Dept. of Pharmacology J.S.S Medical College, Mysuru.

Shastri R D et al. editors, (1st ed.).Vidyotini Hindi Commentary, Charaka Samhita, Chikitsasthan; Chapter 2/4, Verse 36, Page No.89, Varanasi; Chaukhambha Bharati Academy, Reprinted 2005.

Shastri R D et al. editors, (1st ed.).Vidyotini Hindi Commentary, Charaka Samhita, Sutrasasthan; Chapter 10, Verse 26, Page No. 587, Varanasi; Chaukhambha Bharati Academy, Reprinted 2005.

Bendjeddou D, Lalaoui K and Satta D; Immumostimulating activity of the hot water soluble polysacharrides extract of Anacyclus pyrethrum, Alpinia galanga and Citeullus colocynthis. J. Ethnopharmacol, 2003 Oct;88(2-3):155-60.

Sharma Vikas, Thakur Mayank, Chauhan Nagendra Singh, Dixit Vinod Kumar; Immunomodulatory activity of petroleum ether extract of Anacyclus pyrethrum Pharmaceutical Biology, 2010; 48(11): 1247–1254.

Sukumaran K and Kuttan R; Inhibition of tobacco-induced mutagenesis by Eugenol and plant extracts available at http://www.ncbi.nlm.nih.gov/pubmed/7753104.

Burgess I F, Brown C M and Burgess N A; Synergized pyrethrin mouses a new approach to head lice eradication; Pyrethrum post; Vol-19;no.2;Dec 1994;pp 41-46.

Panchal G M, Bhat Venkatakrishna, Devasankaraiah G, Gopalakrishna G, Patel V K; Anaesthetic activity of Anacyclus pyrethrum in laboratory animal; Indian Journal of Pharmacology 2001; 33:296.

Devasankariah G, Gopala Krishna GVK, Patel Rupal V, Patel H, Bhatt Venkata Krishna; A clinical appraisal of AP root extract in dental patients. Phytotherapy Research, 1992; 6(3): 158-159.

Sujith K, C Ronald Darwin, Sathish, Suba V; Memory-enhancing activity of Anacyclus pyrethrum in albino Wistar rats Asian Pacific Journal of Tropical Disease (2012) 307-311.

Sujith, Neuropharmacological profile of ethanolic extract of Anacyclus pyrethrum in Albino Wister rats; IJPSR, 2011; Vol. 2(8): 2109-2114.

Badhe S R, Badhe R V, Ghaisas M, Chopade V V, Deshpande A D; Evaluations of antidepressant activity of Anacyclus pyrethrum root extract; International Journal of Green Pharmacy 2010;4:79-82.

Mishra and Mathur; Testing Efficacy of Herbal drug “Fortege” in Treatment of Metal Induced Infertility in male mice; IJPSR, 2013; Vol. 4(4): 1521-1523.

Wafaa M El-Kholy, Faried A E, Hemieda and Nehal A El-Zarif; Protective effect of aqueous extract of Anacyclus pyrethrum root on atrazine-induced male reproductive disorders in rats; International Journal of Advanced Research Volume 3, Issue 10, 1701 – 1715, 2015.

Organization for Economic Cooperation and Development (OECD) guidelines for acute toxicity of chemicals. No. 425 Adopted: 3 October 2008.

Kumar V K, Lalitha K G; Acute Oral Toxicity Studies of Anacyclus pyrethrums DC root in Albino rats. International Journal of Pharmacy and Pharmaceutical Sciences Vol 5, Issue 4, 675-678, 2013.

Sharma P V, Dravyaguna Vigyana Vol. II, Chapter VII, Page No.-579. Varanasi; Chaukhambha Bharati Academy.

Boulos L, Anacyclus pyrethrum (L.) Link in: Medicinal Plants of North Africa. Reference Publications Inc 1983; 54.

Ibne Hubal. Kitab Al Mukhtarat Fil Tib. Urdu translation by CCRUM Vol. 2. New Delhi: Ministry of Health and Family Welfare; 2005: 66,222.

Ibne Rushd. Kitabul Kulliyat. Urdu Translation by CCRUM. New Delhi: Ministry of H & FW, Govt. of India; 1987: 299, 300.

Wie M B, Won M H, Lee K H, Shin J H, Lee J C, Suh S W et al. “Eugenol Protects Neuronal Cells from Excitotoxic and Oxidative Injury in Primary Cortical Cultures,” Neuroscience Letters, Vol. 225, No. 4, 1997, pp. 93-96.

Razi AMB Zakaria, “Al-Hawi-Fil-Tib Urdu Translation,” CCRUM Publication, New Delhi, 1997.

Khare C P, Indian Medicinal Plants: An Illustrated Dictionary. New Delhi: Published by Springer; 2007. p. 46-47.

Nadkarni A K, Indian Materia Medica (popular prakashan), Mumbai; pp: 97-98, 1989.


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